TNFSF10 and acute myocardial infarction: This is similar to the findings of several previous studies, in which serum TRAIL levels were negatively related to the severity of coronary heart disease [27], lower serum TRAIL levels were associated with worse outcomes in patients with acute myocardial infarction [28], and higher TRAIL levels in patients with advanced heart failure were associated with an improved prognosis [12,29].