Overall, eighteen studies (Table 1) [21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38] analysed the potential healing enhancement after intraoperative application of osteoinductive factors, such as BMPs, and PRP and osteogenetic factors (MSCs) in long bone fractures. The gene discussed is CLN5; the disease is Recurrent long bone fractures.