On the other hand, the ability of HRV parameters to predict not only the short-term but also the medium-term COVID-19 outcome [29,35,43,45] or intensive care unit admission [43], and the SDNN ability to foresee the rise in CRP over the next 72 h, [32] seem to support the hypothesis that AD precedes the clinical and laboratory worsening of the disease and COVID-19-related inflammation. The gene discussed is CRP; the disease is COVID-19.