MPO and idiopathic pulmonary fibrosis: In contrast, the factors favoring fibrotic change are nonincreasing levels of CRP or ESR, a decrease or leveling off of the MPO-ANCA titer, expansion of fibrotic change as reticulation with traction bronchiectasis and honeycombing on HRCT without increasing attenuation (i.e., ground-glass opacity [GGO] and consolidation), and pathologically patchy fibrosis as a UIP pattern and/or fibroblastic foci in a lung specimen without prominent inflammatory cells [1,2,3,30,31,33,34,47,48,49,50].