The Cox proportional hazards model analysis was conducted to examine the effect of the covariates, including age, sex, invasion, lymph node metastasis, histology grading, and the tissue CIAPIN1 expression level, showing that only CIAPIN1 is an independent factor for poor prognosis of CCA (HR = 4.01, 95% CI: 1.131–14.195; p = 0.031, Table 2). Here, CIAPIN1 is linked to metastatic malignant neoplasm in the lymph nodes.