CD274 and adenocarcinoma: Interestingly, our recent studies demonstrated that among the ERM proteins, ezrin predominantly controls the plasma membrane localization of PD-L1, possibly via molecular interaction, in human adenocarcinoma cells derived from uterine cervix (HeLa) and colorectum (LS180) cells, in which ezrin is expressed at the highest level among ERM, based on DepMap global gene expression analysis and RT-PCR data [31,32].