Arrhythmic heart sounds on the physical admission exam, AF on the ECG, diastolic blood pressure (DBP), SpO2, the increased values of hemoglobin, hematocrit and NT-proBNP were other factors associated with an increased chance of cardiovascular disease (refer to Table S2 for ORs, CIs, and p-values). This evidence concerns the gene NPPB and atrial fibrillation.