According to the latest WHO classification of tumors of the CNS, IDH wild-type astrocytoma would be diagnosed as GBM if it meets any of the criteria or combinations of TERT promoter mutation, epidermal growth factor receptor (EGFR) amplification, chromosome 7 amplification/chromosome 10 deletion, even if the histological grade is low [3]. The gene discussed is EGFR; the disease is central nervous system neoplasm.