Similar to the results from previous studies investigating associations with T50 in other patient populations, we found that serum fetuin-A and serum phosphorus levels were important and independent determinants of T50 in individuals with PXE, with higher fetuin-A and lower phosphorus concentrations resulting in higher, that is, better, T50 values [14,34]. The gene discussed is AHSG; the disease is pseudoxanthoma elasticum (inherited or acquired).