In addition, bacterially-derived LPSs and amyloids can increase activation of the NF-κB signaling pathway, further exacerbate the gut’s leakiness, and increase the levels of cytokines, such as IL-17 and IL-22, which are involved in the inflammatory process of AD [47] and IBD as well [6]. The gene discussed is NFKB1; the disease is Alzheimer disease.