Among them, increased interleukin-6 (IL-6) has been found during sleep restriction in normal subjects [44] and in OSA patients with objectively documented sleepiness, i.e., a short sleep latency at multiple sleep latency tests, whereas no correlation was shown between IL-6 and subjective sleepiness, as assessed by the Epworth or Stanford Sleepiness scale [45]. The gene discussed is IL6; the disease is obstructive sleep apnea syndrome.