The gene expression analysis including Trp53 and caspases on day 8 after DSS initiation (Supplementary Figure S1C) also supported the results, and given that Ccndbp1 is expressed in various organs, including the colon [14,15,16], based on the results obtained, it can be a therapeutic target for reducing the inflammation and apoptosis in colitis. This evidence concerns the gene TP53 and colitis.