SREBF1 and metabolic dysfunction-associated steatotic liver disease: In this regard, fructose-enriched foods are considered one of the major categories of food directly involved in NAFLD onset and evolution due to its role as a substrate for DNL, which increased the acetil-CoA cellular level and acted as an enhancer for the expression of several enzymes involved in DNL, such as SREBP-1c and ChREBP [115].