A recent study of Horst et al., comparing a group of NAFLD-obese patients with only obesity affected patients, revealed an increase in the hepatic flow of lipogenic substrates, elevated 24-h plasma glucose concentrations, and a considerable insulin concentration as factors directly related to the increase in hepatic DNL without pathway-selective hepatic IR [21]. The gene discussed is INS; the disease is metabolic dysfunction-associated steatotic liver disease.