SREBF1 and Insulin resistance: Additionally, a recent study conducted by Liu et al. emphasized the correlation between the upregulation of H19 and the over-expression of SREBP-1c, ACC1, SCD1, FASN, and PPARγ in a model of NAFLD, highlighting the crucial role of H19 in the development of hepatic insulin resistance by affecting not only genes involved in gluconeogenesis but also in hepatic lipogenesis [111].