Moreover, Nitahara-Kasahara et al. demonstrated that decreases in DS in muscle in addition to myopathy-related phenotypes such as variation in fiber size and spread of the muscle interstitium which caused lower grip strength and decreased exercise capacity, were observed in Chst14–/– mice compared with Chst14+/+ as well as Chst14+/– mice [31,32]. This evidence concerns the gene CHST14 and myopathy.