A bipolar disorder was caused by a variety of homozygous and heterozygous variants in DSEL including the substitution of a nucleotide in the 5′-non-coding region, p.Val287Ile, p.Pro673Ser, p.Tyr730Cys, p.Pro942Ser, and p.Ile1113Met [75] (Table 2). The gene discussed is DSEL; the disease is bipolar disorder.