The reversed replication forks are protected from MRE11 nuclease degradation by BRCA1, BRCA2, RAD51, and components of the Fanconi anemia (FA) complex, such as FANCA, FANCD2, and FANCJ (BRIP1) [43,44,45] (Figure 3d). The gene discussed is BRIP1; the disease is Fanconi anemia.