BRCA1 and breast cancer: Based on the results of meta-analyses, it is certain that contralateral RRM (CRRM) in BC patients with BRCA1/2 GPVs reduces the risk of developing BC in the contralateral breast [60,61,62]; however, the survival benefit of CRRM remains uncertain because the effect of risk-reducing salpingo-oophorectomy (RRSO) cannot be excluded [60,61,62].