VEGFA and glioblastoma: Furthermore, the measurement of the expression of the seven markers involved in the angiogenesis and inflammation pathways of patients with glioblastoma allowed them to establish statistically significant associations between the presence of low levels of IL-8 and the development of coagulation necrosis, high levels of VEGF, the development of ischemic necrosis and high levels of IL-8, and the development of endothelial hyperplasia [248].