TRIM67 and obesity due to melanocortin 4 receptor deficiency: Thus, in this study, with TRIM67 genetically knockout mice and high-fat-diet induced obesity/NAFLD mouse models, we aim to evaluate whether the altered expression of TRIM67 could affect the development and progression of obesity-induced NAFLD and to elucidate the underlying mechanisms, which could provide new aspects for studying TRIM67 and for NAFLD treatment.