NOS2 and myocardial ischemia: Notably, Saussurea involucrata has been reported in recent years to have therapeutic effect against myocardial ischemia by affecting Acetylcholine-activated K+ current [11], regulating lipid peroxidation activation and infracts size [12], and altering cyclic guanosine monophosphate (cGMP), inducible nitric oxide synthase (iNOS), and 3-nitrotyrosine concentrations [13], which correspond to the traditional Chinese medicine effect of Saussurea involucrata for clearing the meridian and promoting blood circulation.