For example, rutin has been reported to significantly reduce serum cGMP and nitric oxide (NO) levels, and inhibit iNOS and 3-nitrotyrosine (3-NT) [13], while showing cardioprotective function in a rat model of ischemia-reperfusion-induced myocardial infarction [12,35]. This evidence concerns the gene NOS2 and myocardial infarction.