Increased protein expression of TNFSF12/TWEAK is detected in the renal cortex of patients with lupus nephritis (LN) and treatment of mesangial cells with TNFSF12/TWEAK promotes macrophage chemotaxis, probably through the chemotactic factors that TNFSF12/TWEAK induces [130]. This evidence concerns the gene TNFSF12 and lupus nephritis.