WNT1-inducible-signaling pathway protein 1 (WISP1), which has been found to regulate kidney fibrosis through TGFβ [27] and whose serum levels are elevated in CKD patients [28], promoted the secretion of many factors too (CCL2, CCL5, CXCL10, TNF10, PROK1, IL-3). Here, PROK1 is linked to chronic kidney disease.