In the presence of flg22, flg22-bound FLS2LRR outcompetes BIR1LRR for binding to BAK1LRR from the BIR1LRR–BAK1LRR complex and forms a signaling competent flg22–FLS2LRR–BAK1LRR complex [36] Based on this structural study, BIR1 functions to keep BAK1-mediated cell death signaling under tight control, thus preventing undesired autoimmunity, and therefore, it is possible that the autoimmunity in bir1-1 or GmBIR1-silenced plants is a result of activation of BAK1-mediated PTI. This evidence concerns the gene BAK1 and Autoimmunity.