Previous data documented a significant increase in the number of P2RX7+ cells in the NASH-affected liver biopsies compared to healthy controls, although the P2RX7 mRNA was similar; this was coupled with increased NLRP3, IL-1β, Caspase-1, and AIM2 mRNA [20]; therefore, our observations are somehow confirmatory of the presence of the P2X7R in resident hepatic cells of patients with metabolic liver disease. This evidence concerns the gene P2RX7 and metabolic dysfunction-associated steatohepatitis.