Several studies conducted in mouse and cellular models have documented a significant mRNA expression of the NRLP3-inflammasome components and P2X7R in case of HCV infection [9,10] and non-alcoholic steatohepatitis (NASH) [11,12], although studies addressing the link of P2X7R and P2X4R with non-alcoholic fatty liver disease (NAFLD) are scanty. The gene discussed is P2RX4; the disease is metabolic dysfunction-associated steatohepatitis.