NLRP3 and liver disorder: The effect of liver disease on gene expression was confirmed in multivariable models after adjustment for potential confounders (age, sex, BMI): all the inflammasome components (P2X7R, P2X4R, NLRP3, CASP1, AIM2, IL-2) were significantly related to the liver disease (0.0007 < p <0.037).