Hence, in this case, the negative correlation of TLR5 with OLFM2 mRNA expression in the liver makes sense given that OLFM2 increases as NAFLD worsens, while TLR5 in the gut could be decreased due to the high inflammation pattern induced by intestinal dysbiosis and liver damage. The gene discussed is OLFM2; the disease is metabolic dysfunction-associated steatotic liver disease.