NFKB1 and cancer: Given that the exposure of immortalized breast epithelial cells to IL-6 is sufficient to induce an epigenetic switch mediated by NF-κB and the emergence of TNBC-like cells [130], it appears that any attempt to treat or prevent cancer that produces toxicity has the potential to result in the dedifferentiation of normal and cancerous cells with the adoption of preexisting and robust malignant cellular states.