Altogether, the endogenous tendency of the most malignant subtypes of carcinomas to adopt a basal (fibroblastic) shape derives from DNA damage that, in turn, generates a permanent ATM activation and constitutive higher levels of NF-κB, secretion of cytokines, and the acquisition of the features of a mesenchymal stem cell with malignant behavior [115]. The gene discussed is ATM; the disease is carcinoma.