Mutations in BEST1 have also been associated with other clinically distinct retinal degenerative diseases including Autosomal Recessive Bestrophinopathy (ARB), Autosomal Dominant Vitreoretinochoroidopathy (ADVIRC), Adult Vitelliform Macular Degeneration (AVMD), and Retinitis Pigmentosa 50 (RP50). Here, BEST1 is linked to adult-onset foveomacular vitelliform dystrophy.