BACE1 and Alzheimer disease: In neuron-specific human BACE1 knock-in mice, an animal model of sporadic AD, fenretinide (0.04% w/w in diet, approximately corresponding to 40–50 mg/kg/die) has been shown to reduce adiposity gain and serum leptin, a key regulator hormone in the control of body weight, metabolism and glucose homeostasis [87].