HMGB1 and cancer: It was previously shown in cancer cells that knock down HMGB1 decreased erastin-induced ferroptosis through the RAS-JNK/p38 pathway [137], and a very recent study demonstrated that HMGB1 inhibition by glycyrrhizin administration decreased neuronal ferroptosis in both a cell culture oxygen-glucose deprivation model and after neonatal HIBI in rats in vivo [138].