Ad (i) and (ii): It is tempting to speculate that adipose, muscle, endothelial and blood cells act as donor and acceptors cells for the regulation of lipid synthesis by transferred GPI-APs based on the presented data and the following rationale: Storage of lipids in insulin target cells and tissues that are not destined for (e.g., muscle in contrast to adipose) is regarded as cause for or consequence of their insulin-resistant state as prevalent during type II diabetes. This evidence concerns the gene INS and type 2 diabetes mellitus.