Infection with live SARS-CoV-2 activated the coagulation cascade by promoting the release of endothelial cytokines, including IL-1α, IL-6, and TNF-α, and the expression of endothelial pro-thrombotic markers, such as von Willebrand factor and plasminogen activator inhibitor-1 (Figure 2B) [145]. The gene discussed is TNF; the disease is infection.