KIF11 heterozygous nonsense mutations [42] cause microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (OMIM: 152950), while PIEZO1 homozygous or compound heterozygous loss-of-function mutations [43] cause lymphatic malformations 6 (OMIM: 616843). Here, PIEZO1 is linked to lymphatic malformation.