Mosaic gain-of-function mutations [34] in AKT1 cause Proteus syndrome (OMIM: 179620), while somatic gain-of-function mutations [35,36,37] in PI3KA cause CLAPO (OMIM: 613089) and CLOVE (OMIM: 612918) syndromes. This evidence concerns the gene AKT1 and Proteus syndrome.