LEP and obesity due to melanocortin 4 receptor deficiency: Among them, obesity seems to be a crucial driving force in their development, since the overabundance of adipose tissue is the source of manifold pro-inflammatory mediators—immunological factors (dendritic cells, cytokines, T-cells, macrophages, and chemokines), adipokines (adiponectin and leptin), chemokines and cytokines—which promote oxidative stress, endothelial dysfunction, and atherosclerosis [11,12].