MBP and systemic lupus erythematosus: Analysis of the kinetic parameters of the antibody-mediated MBP-hydrolysis showed that the Km values (5.2–150 mkM) of IgG-dependent proteolytic activity are relatively higher in BD patients in comparison with MS patients (0.9–5.0 mkM) [49], SLE patients (0.6–2.7 mkM) [35], schizophrenia patients (4.3–12.4 mkM) [37] and canonical proteases.