In this paper, we reported that CDK1 promotes the migration of HNSCC cells by modulating ∆Np63α: the overexpression of CDK1 enhances cell migration (Figure 5B,C) and significantly impairs the migration inhibition induced by the overexpression of wild-type ∆Np63α, but not that by its T123A mutant (Figure 6B,C); knockdown of CDK1 induces an inhibition of cell migration (Figure 5F,G), which can be partially rescued by the simultaneous ablation of ∆Np63α (Figure 7). Here, CDK1 is linked to head and neck squamous cell carcinoma.