The role of TRPC5 in therapy resistance is not confined to breast cancer, as its upregulation has been also identified in 5-fluorouracil resistant human colorectal cancer cells, where TRPC5 overexpression determines the overproduction of ATP-binding cassette subfamily B member 1 (ABCB1), a pump involved in drug resistance through the export of cytotoxic drugs, via Ca2+ entry and activation of Ca2+-dependent Wnt/β-catenin signalling pathway and in a glycolysis-dependent manner [201,202,203] (Figure 2). The gene discussed is ABCB1; the disease is colorectal cancer.