On the other hand, extracellular acidic pH activated TRPV1 and enhanced lymphatic endothelial cells’ proliferative, migratory and invasive abilities via activation of NF-κB transcription factor and consequent upregulation of IL-8, a lymphangiogenic factor, contributing to lymphatic metastasis in tumour acidic microenvironment context [79] (Figure 1). The gene discussed is TRPV1; the disease is neoplasm.