TRPV2 and hepatocellular carcinoma: Wang and colleagues did not report any change in TRPV2 expression following hypoxia exposure in human PASMCs [110], but H2O2-mediated oxidative stress upregulated TRPV2 gene and protein expression in two different human hepatoma cell lines, with induction or cell death by activating pro-apoptotic proteins and by inhibiting pro-survival ones, and by enhancing the sensitivity of human hepatoma cells to oxidative stress-associated chemicals [111] (Table 2).