TRPV4 is a heat-activated and mechanosensitive channel deregulated in different cancer cells, acting mostly as a pro-tumour factor, enhancing cancer cells’ migration and metastasis through the activation of AKT and Rho/ROCK1/cofilin cascade, extracellular remodelling, proliferation and angiogenesis via activation of NFAT and PI3K signalling pathway [166,167,168,169,170,171,172], although a tumour-suppressive role has also been reported, especially in tumours expressing high TRPV4 levels [173,174] (Figure 1 and Figure 3). Here, CFL1 is linked to cancer.