TRPA1 and neuroblastoma: HEK293 cells expressing human and rodent TRPA1 showed a specie-specific activation of the channel, where only hTRPA1 generated a membrane current when exposed to different extracellular acidic environments (pHe 6.4-5.4) reaching the maximal response at acidic pHe 5.4; this specific effect for hTRPA1 was confirmed by Ca2+ imaging experiments in HEK293 cells as well as in DRG neurons derived from TRPV1/TRPA1−/− mice and in neuroblastoma ND7/23 cells expressing hTRPA1, where only hTRPA1 induced an increase in Ca2+ entry when exposed to acidic pHe.