TRPM2 and cancer: Oxidative-stress-mediated TRPM2 activation and consequent rise in intracellular Ca2+ levels might promote cancer progression also by activating Ca2+-dependent K+ channels, such as the large-conductance voltage-dependent BK channel and the medium-conductance voltage-independent KCa3.1 channel, as reported in melanoma cells [101], which role in cancer hallmarks, such as cell viability and cell migration and invasion have been described [59].