TRPC6 and Hepatic fibrosis: Hypoxia also upregulated TRPC6 in hepatic stellate cells via HIF-1α/Notch1 pathway, leading to TRPC6-mediated Ca2+ influx and the downstream activation of Ca2+-dependent nuclear factor of activated T-cells (NFAT) transcription factor and SMAD2/3-dependent TGF-β signalling, which activation resulted in the expression of ECM proteins, such as collagen type I, that facilitate hepatic stellate cells’ fibrotic activation and promotes hepatic fibrosis, strongly linked to arise of hepatocellular carcinoma [124] (Table 2; Figure 1 and Figure 3).