In the next section, we will present an updated view of the recent literature on the role of Piezo channels, transient receptor potential Ca2+-permeable ions channels (TRPs) and the so-called store-operated Ca2+ channels (SOCs) on normal and cancer cells, which activity and signalling transduction are directly affected by two features of the tumour microenvironment: hypoxia and acidosis. The gene discussed is CISH; the disease is cancer.