TRPC1 upregulation has been reported in several cancers, such as pancreatic cancer, where it potentiates BxPc3 cells’ migration via Ca2+-dependent activation of PKCα [193], and breast cancer, where it exerts a pro-proliferative role in MCF-7 cells by mediating Ca2+ influx induced by KCa3.1 activation [194] and via Ca2+-dependent ERK1/2 activation [195]. This evidence concerns the gene TRPC1 and breast cancer.