Several studies has revealed the positive effect of TRPV6 activity on tumour progression through the activation of Ca2+-dependent signalling pathways [176], promoting cancer proliferation and cell survival in prostate cancer cells by activating the Ca2+-dependent NFAT transcription factor [177,178], invasion of breast cancer cells through Ca2+/Calmodulin (CaM)-dependent kinases, such as CaMKII [179,180], cell survival, proliferation, and invasion in pancreatic cancer cells [181] and tumour growth in in vivo ovarian adenocarcinoma xenograft mouse model [182] (Figure 1 and Figure 3). Here, TRPV6 is linked to neoplasm.