The hypoxia response is not limited to glycolytic flux, as it also enhances the expression of VEGF and other pro-angiogenic factors and promotes tumour progression by inducing epithelial–mesenchymal transition (EMT) [25], cell survival in moderate hypoxic conditions via autophagy, cell death via the same mechanism but in presence of severe hypoxic conditions [26], and by promoting cancer cells’ invasion and metastasis in acute hypoxic conditions (from minutes up to 72 h exposure in vitro). The gene discussed is VEGFA; the disease is neoplasm.