In a lipopolysaccharide (LPS)-induced AKI model, vitamin D3 pretreatment had different effects including (1) significantly attenuating LPS-induced renal inflammatory cytokines, chemokines, and adhesion molecules [33] and reinforcing the interaction between renal VDR and the NF-κB p65 subunit; (2) alleviating LPS-induced renal glutathione (GSH) depletion and lipid peroxidation and attenuating serum and renal NO production and protein nitration by regulating oxidant and antioxidant enzyme genes [34]. This evidence concerns the gene NFKB1 and acute kidney injury.