Appropriate vitamin D supplements can prevent some chronic diseases, such as diabetes mellitus, cardiovascular disease, and chronic kidney disease (CKD), by regulation of oxidative stress through the following ways: inducing the expression of several molecules involved in the antioxidant defense system including glutathione, glutathione peroxidase, superoxide dismutase (SOD); suppressing the expression of nicotinamide adenine dinucleotide phosphate hydrogen (NADPH) oxidase [1,2,3,4,5]. This evidence concerns the gene SOD1 and chronic kidney disease.