Strikingly, our data revealed a significant increase in the cytoplasmic expression of FoxO3 (Figure 7) following the dysregulation of the α1-Na/K-ATPase signalosome and subsequent activation of the PI3K → Akt cascade in the untreated cancer cells, indicating an upregulation in the nuclear to cytoplasmic export of the FoxO3 protein. The gene discussed is FOXO3; the disease is cancer.