Notably, canonical pathways that were significantly activated by VEGF (e.g., insulin secretion signaling pathway, tumor microenvironment pathway, oncostatin M signaling, ERK5 signaling, regulation of epithelial-mesenchymal transition by growth factors pathway, and unfolded protein response) were predicted to be significantly inactivated (z-score ≤ −2) with KDR knockdown. This evidence concerns the gene INS and neoplasm.