Of the significantly enriched pathways associated with cluster 3 genes, pathways involved in cellular movement (e.g., pulmonary healing signaling pathway and IL-8 signaling) and cellular stress (pulmonary fibrosis idiopathic signaling pathway and hepatic fibrosis signaling pathway) were predicted to be significantly activated (z-score ≥ 2) in VEGF- treated HRMECs with STAT3 knocked down compared to control (Figure 4F). This evidence concerns the gene CXCL8 and pulmonary fibrosis.