Keywords included melanoma, TNBC, immunotherapies, PD-1, PD-L1, CTLA-4, RAS, BRAF, MEK, ERK, PI3K, AKT, mTOR, the targeted inhibitors listed in Figure 2, and ICIs (ipilimumab, nivolumab, pembrolizumab, atezolizumab, spartalizumab, durvalumab, and their alternative names). The gene discussed is AKT1; the disease is melanoma.