CYBB and leukemia: A combined strategy of in vitro and in vivo experiments using a patient-derived AML xenograft model in NSG mice demonstrated that mitochondria transfer from stroma cells to AML blasts occurs via leukemia-derived tunneling nanotubes and that ROS levels regulate this transfer through the NOX-2 signaling pathway; mitochondria transfer exerts a pro-leukemic effect in these mice [186].