AHR and acute myeloid leukemia: On the other hand, in a human in vitro AML model used for high-throughput screening of small molecules, it was described that compounds that suppress the aryl-hydrocarbon receptor pathway have a key influence in preventing AML cell differentiation; those cells were cultured in free-serum media, analyzed under hypoxia, and cultured into different surfaces (plastic, glass and rodent fibroblasts support), showing similar results under all tested conditions [35].