In the same context, a transgenic murine model for AML (based on MLL-AF9 fusion gene expression and DsRed reporter) was designed to obtain a high number of LSC to perform a high-throughput screening of small molecules with anti-leukemic properties in a co-culture system, with primary BM-MSC derived from actin-GFP mice or GFP-expressing BM stroma-derived OP9 cells [90]. This evidence concerns the gene KMT2A and acute myeloid leukemia.