NLRP3 and obesity due to melanocortin 4 receptor deficiency: Development of asthma was shown to be induced by obesity, as mice fed a high-fat diet (HFD) rapidly developed insulin resistance, hepatic steatosis, airway hyperreactivity, and increased expression of NLRP3 and IL-1β in adipose tissue and the lung as compared with lean mice fed chow [101,108].