However, when NLRP3 was genetically depleted, mice fed an HFD showed a significant reduction in airway hyperreactivity, insulin resistance, and hepatic steatosis as compared with their wild-type littermates [101,108], indicating that the inflammasome complex has a key role in the development of these obesity-associated complications. Here, NLRP3 is linked to obesity due to melanocortin 4 receptor deficiency.