NLRP3 and lung disorder: Moreover, NLRP3-derived cytokines (e.g., IL-1β, IL-18) appear to be the main inducers of a cytokine cascade (involving IL-23, IL-17, IL-26, IL-6, IL-13, and IL-5) that is responsible for the development of pulmonary diseases in morbidly obese subjects (Figure 1).