In our previous work, we showed that nutritional overload in obesity may enhance the expandability of VAT, specifically over SAT, which may occur via downregulation of expression of the histone deacetylases sirtuin 1 (SIRT1) and sirtuin 2 (SIRT2) in the resident adipose staminal cells (ASCs) [35]. Here, SIRT1 is linked to obesity due to melanocortin 4 receptor deficiency.