NLRP3 and obesity due to melanocortin 4 receptor deficiency: It has been showed that NLRP3 expression and activity are involved in adipose tissue dysfunction and inflammation in obesity, in addition to their involvement in Treg/Th17 imbalance [104] and with lung health in patients with COPD, asthma, rheumatoid lung disease, and COVID-19 [22,105,106,107].