Capillary-electrophoresis coupled to mass spectrometry (CE-MS) analysis applied to CSF led to an AD diagnostic panel consisting of 12 signals, and only 5 of them were identified as following peptides or peptides fragments: ProSAAS precursor (217–242): AADHDVGSELPPEGVLGALLRV, chromogranin A (322–339): SGELEQEEERLSKEWEDS, phospholemman (21–41): ESPKEHDPFTYDYQSLQIGGL, clusterin (apolipoprotein-J) (22–49): DQTVSDNELQEMSNQGSKYVNKEIQNA, and VGF (26–59): GRPEAQPPPLSSEHKEPVAGDAVPGPKDGSAPEV [79]. This evidence concerns the gene VGF and Alzheimer disease.