However, in the acid (HCl)-induced ALI model, thrombin and PAF produced Cx40 GJ channels’ inhibition and genetic deficiency mitigated vascular endothelial permeability via the upregulation of Rock1, causing the subsequent phosphorylation of Myosin Phosphatase target subunit (MYPT)1 and MLC20 [189]. Here, GJA5 is linked to acute respiratory distress syndrome.