Conversely, based on previous findings that demonstrated the analgesic effect of cooling compounds that activate TRPM8 [101,102], Colvin et al. [98] described a case report of a MM patient with a grade IV bortezomib-induced neuropathic pain treated with menthol to activate TRPM8 channel and to successfully reverse peripheral neuropathy. Here, TRPM8 is linked to peripheral neuropathy.