Therefore, IR activated the expression of genes related to the mitogen-activated protein kinase (MAPK) signaling pathway, proteoglycans in cancer, lipid and atherosclerosis, Rap1 signaling pathway, etc., and suppressed the expression of genes related to the neuronal system of glutamatergic synapse, oxytocin, calcium signaling pathways, etc., in IH, regardless of the type of control used (SO-r or IR-c). This evidence concerns the gene WNK2 and isolated hemihyperplasia.