There are many different cytokines reported as biomarkers for cerebral ischemia, such as IL-1β, IL-6, IL-8, IL-12, IL-15, IL-16, IL-20, IL-18, IL-23/IL-17, and so on, which play a pro-inflammatory role after ischemic stroke; ILs that have anti-inflammatory effects on ischemic stroke include IL-2, IL-4, IL-10, IL-13, IL-19, IL-33, and so on, as reported recently [150]. Here, IL16 is linked to ischemic stroke.