To confirm the finding, we also compared the perturbation following shRNA-mediated knockdown of SREBP-1 between unsorted parental cell lines and resistant clone that also resulted in an attenuated CD133 activity, reduced generation of tumor sphere, and suppression of colony formation in A549 NSCLC cell line (Supplementary Figure S2A–C). Here, PROM1 is linked to non-small cell lung carcinoma.