An important regulator of AML cell autophagy is bromodomain containing protein 4 (BRD4), which works either by direct modulation of autophagy-related genes, or by increasing ROS species release by KEAP1 (kelch-like ECH-associated protein 1), followed by blocking the NRF2 (nuclear factor, erythroid 2-like 2) antioxidant pathway [78]. Here, KEAP1 is linked to acute myeloid leukemia.