CSD contains an immunoreceptor tyrosine-based activation motif (ITAM), the region responsible for modulation of BCR signaling [94,105,106,107] As was shown by Lu et al. [106], in human epithelial cells, tyrosine residues within the sequence of ITAM are essential for SYK activation, and SYK-LMP-2A interaction may contribute to the development of NPC [106]. Here, SYK is linked to nasopharyngeal carcinoma.