PAG1 and neoplasm: We could further validate the up-regulation of other notable Hif-1α target genes, such as the vascular endothelial growth factor A (Vegfa), serpin family E member 1 (Serpine1), and the more recently characterized HIF target phosphoprotein membrane anchor with glycosphingolipid microdomains 1 (Pag1), which all have a link with cancer progression and the tumor microenvironment [31,32,33,34,35].