PRRT2 and Hyperglycemia: Interestingly, hyperglycaemia-induced PKC activation has been reported to have significant intracellular and intercellular consequences, affecting endothelial permeability, vasoconstriction, extracellular matrix synthesis/turnover, cell growth, cytokine activation and leukocyte adhesion, thus emerging as a potential therapeutic target to prevent diabetic vascular complications [17].