However, in terms of gene expression and protein expression after long-term hyperglycaemia, a significant reduction of GLUT4 expression was detected (gene: 2-fold less, WT30L vs. KE230L, p < 0.0001, t-test; protein 3-fold less, WT30L vs. KE230L, p < 0.01, t-test) (Figure 1B,C, respectively). Here, SLC2A4 is linked to Hyperglycemia.